Caldesmon is a regulatory protein in smooth muscle that binds to tropomyosin and actin in thin filaments. when caldesmon binds to thin filaments, it inhibits the myosin atpase. this action of caldesmon is inhibited when caldesmon is phosphorylated by protein kinase c or when caldesmon binds ca2+-calmodulin. imagine that a hormone binding to its receptor on a smooth muscle cell activates the mechanisms shown in the slide entitled “dag/ip3 system” in the cell communication lecture. what would be the likely effect of this hormone on contraction of the smooth muscle cell?
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